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Shih-Jen Tsai Selected Research

Fibrinolysin

6/2010The tissue plasminogen activator/plasmin system may act through cleavage of pro-BDNF to increase risk of substance abuse.
5/2009Statins may act through increasing tissue plasminogen activator/plasmin activity to lower risk of Alzheimer's disease.
2/2009Is dysfunction of the tissue plasminogen activator (tPA)-plasmin pathway a link between major depression and cardiovascular disease?

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Shih-Jen Tsai Research Topics

Disease

47Major Depressive Disorder (Major Depressive Disorders)
12/2022 - 01/2003
42Schizophrenia (Dementia Praecox)
04/2022 - 01/2002
28Alzheimer Disease (Alzheimer's Disease)
01/2022 - 01/2002
21Bipolar Disorder (Manic Depressive Psychosis)
09/2022 - 01/2003
19Treatment-Resistant Depressive Disorder
03/2022 - 01/2008
17Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
12/2021 - 06/2003
16Dementia (Dementias)
01/2022 - 11/2007
11Cognitive Dysfunction
09/2022 - 07/2003
11Body Weight (Weight, Body)
01/2021 - 09/2002
10Mood Disorders (Mood Disorder)
10/2021 - 01/2003
10Psychotic Disorders (Schizoaffective Disorder)
11/2011 - 09/2002
8Mental Disorders (Mental Disorder)
01/2021 - 01/2007
7Rett Syndrome (Rett's Disorder)
10/2016 - 01/2006
6Inflammation (Inflammations)
01/2022 - 11/2010
6Obesity
10/2021 - 12/2010
6Body Weight Changes
12/2011 - 09/2002
5Parkinson Disease (Parkinson's Disease)
01/2022 - 01/2002
5Depressive Disorder (Melancholia)
01/2021 - 04/2007
5Weight Gain
10/2011 - 11/2002
4Mania (Manias)
01/2022 - 01/2004
4Anxiety Disorders (Anxiety Disorder)
01/2021 - 01/2020
4Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2017 - 02/2011
4Substance-Related Disorders (Drug Abuse)
11/2016 - 10/2005
4Genetic Predisposition to Disease (Genetic Predisposition)
10/2016 - 10/2003
3Sexually Transmitted Diseases (Sexually Transmitted Disease)
08/2021 - 12/2019
3Neurodevelopmental Disorders
10/2016 - 01/2007
3Neurocognitive Disorders (Clerambault Syndrome)
08/2010 - 04/2003
3Autistic Disorder (Autism)
01/2006 - 01/2005
2Autism Spectrum Disorder
12/2021 - 01/2021
2Overweight
10/2021 - 01/2021
2Epilepsy (Aura)
04/2021 - 01/2006
2Seizures (Absence Seizure)
04/2021 - 01/2005
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2021 - 09/2011
2Stroke (Strokes)
01/2020 - 01/2013
2Infections
10/2019 - 01/2018
2Lymphoma (Lymphomas)
01/2018 - 01/2013
2Hyperlipidemias (Hyperlipidemia)
01/2018 - 03/2005
2Fibrosis (Cirrhosis)
01/2013 - 01/2013
2Disease Progression
08/2012 - 01/2006
2Personality Disorders (Personality Disorder)
01/2012 - 11/2011

Drug/Important Bio-Agent (IBA)

47Antidepressive Agents (Antidepressants)IBA
04/2022 - 01/2003
43Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2021 - 01/2003
27Antipsychotic Agents (Antipsychotics)IBA
06/2022 - 09/2002
20CytokinesIBA
12/2022 - 06/2003
16KetamineFDA LinkGeneric
03/2022 - 01/2019
13Biomarkers (Surrogate Marker)IBA
11/2022 - 09/2014
9Clozapine (Clozaril)FDA LinkGeneric
06/2013 - 09/2002
8Nerve Growth Factors (Neurotrophins)IBA
04/2017 - 01/2003
7Proteins (Proteins, Gene)FDA Link
01/2018 - 12/2003
6Biological ProductsIBA
01/2022 - 01/2007
6Dopamine (Intropin)FDA LinkGeneric
08/2017 - 01/2002
5Serotonin (5 Hydroxytryptamine)IBA
12/2021 - 01/2004
5Proton Pump InhibitorsIBA
04/2021 - 01/2018
5Glutamic Acid (Glutamate)FDA Link
01/2021 - 09/2005
5Interleukin-1beta (Interleukin 1 beta)IBA
10/2017 - 06/2003
5Therapeutic UsesIBA
09/2008 - 06/2003
4Hormones (Hormone)IBA
04/2022 - 01/2021
4Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
12/2021 - 01/2004
4Dopamine Receptors (Dopamine Receptor)IBA
01/2021 - 09/2003
4Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
06/2018 - 01/2004
4Tissue Plasminogen Activator (Alteplase)FDA Link
12/2017 - 02/2009
4Quetiapine Fumarate (Seroquel)FDA Link
04/2014 - 12/2002
4Risperidone (Risperdal Consta)FDA LinkGeneric
04/2014 - 01/2003
4Olanzapine (Zyprexa)FDA Link
06/2013 - 04/2003
4N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
01/2010 - 01/2002
4Fluoxetine (Prozac)FDA LinkGeneric
02/2009 - 08/2003
4Adenosine A2A Receptor (Adenosine A2A Receptors)IBA
10/2006 - 01/2005
3Amisulpride (Solian)IBA
01/2022 - 01/2003
3LithiumIBA
12/2021 - 01/2006
3Interleukin-6 (Interleukin 6)IBA
10/2021 - 01/2005
3Methyl-CpG-Binding Protein 2IBA
10/2016 - 01/2007
3Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
04/2011 - 01/2002
3FibrinolysinFDA Link
06/2010 - 02/2009
3Aripiprazole (Abilify)FDA Link
03/2010 - 01/2005
3Peptides (Polypeptides)IBA
12/2008 - 01/2007
3Triglycerides (Triacylglycerol)IBA
11/2005 - 04/2003
2gamma-Aminobutyric Acid (GABA)IBA
01/2022 - 08/2017
2Glucose (Dextrose)FDA LinkGeneric
01/2022 - 03/2005
2Valproic Acid (Depakote)FDA LinkGeneric
12/2021 - 09/2008
2Lamotrigine (Lamictal)FDA LinkGeneric
12/2021 - 01/2008
2Indicators and Reagents (Reagents)IBA
01/2021 - 01/2016
2Acetaminophen (Paracetamol)FDA LinkGeneric
01/2021 - 10/2019
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2020 - 12/2003
2Neuroprotective AgentsIBA
01/2020 - 01/2006
2Monoamine Oxidase (MAO)IBA
06/2019 - 09/2005
2Apolipoproteins E (ApoE)IBA
04/2017 - 07/2014
2Amyloid beta-PeptidesIBA
03/2016 - 12/2008
2Amyloid (Amyloid Fibrils)IBA
03/2016 - 01/2012
2Paliperidone PalmitateFDA Link
06/2015 - 02/2013
2ApolipoproteinsIBA
07/2014 - 03/2008
2Interleukin-1alpha (Interleukin 1 alpha)IBA
11/2013 - 06/2003
25-HT1A Serotonin ReceptorIBA
02/2013 - 10/2006
2EnzymesIBA
01/2012 - 09/2005
2antiarrhythmic peptide (AAP)IBA
12/2011 - 06/2010
2Varenicline (Chantix)FDA Link
11/2011 - 07/2009
2Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
09/2011 - 01/2002
2ziprasidone (Geodon)FDA Link
06/2010 - 08/2005

Therapy/Procedure

8Therapeutics
01/2022 - 01/2007
5Transcranial Magnetic Stimulation
01/2021 - 03/2002
2Drug Therapy (Chemotherapy)
08/2010 - 01/2007